Crystal Structure of Heterotetrameric Sarcosine Oxidase
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چکیده
Introduction The concentration of serum creatinine is widely used as an indicator of renal function. Sarcosine oxidase (SO) has been used in the enzymatic determination of creatinine in the clinical laboratory. SO has been isolated from various bacterial strains. It was first purified from Corynebacterium sp. U-96 (SO-U96) and shown to be a heterotetrameric enzyme. SO-U96 is a complex, bifunctional enzyme that catalyzes both sarcosine oxidation and the synthesis of 5,10methylenetetrahydrofolate. SO-U96 contains four
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تاریخ انتشار 2006